ON044580
ON044580 is an α-benzoylstyrylbenzyl thioether compound that acts as a non-ATP-competitive JAK2 inhibitor, effective against both wild-type and V617F mutant forms. It suppresses proliferation and induces apoptosis in JAK2V617F-positive and Imatinib-resistant CML cells, and also inhibits BCR-ABL (including T315I mutant), making it a research tool for myeloproliferative neoplasms.
Product Specifications
CAS Number
1035199-04-2
Smiles
O=[N+] ([O-]) C (C=C1/C=C (SCC2=CC=C (C=C2) Br) \C (C3=CC=C (C=C3) C (O) =O) =O) =C (C=C1) F
Molecular Formula
C23H15BrFNO5S
Molecular Weight
516.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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