CA IX-IN-2

CAIX-IN-2 (Compound 9o) is a potent carbonic anhydrase inhibitor selective for CAIX/CAXII, with cellular IC50 values in the low micromolar range against various cancer lines. It induces cell cycle arrest, apoptosis, and mitochondrial dysfunction in vitro and has shown antitumor efficacy in mouse models, supporting its use in oncology and cancer metabolism research.