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PROTAC SMARCA2 degrader-5

PROTACSMARCA2 degrader-5 (Compound I-425) is a potent, cell-permeable PROTAC that induces degradation of the SWI/SNF catalytic subunits SMARCA2 (DC50 <100 nM) and SMARCA4. It serves as a critical chemical probe for studying SWI/SNF complex function in oncology research, with demonstrated activity in cellular models like MV411 and A549 cell lines.

Product Specifications

CAS Number

2568277-68-7

Field of Research

Neuroscience

Smiles

C (C12CCC (C (N[C@H] (C (=O) N3[C@H] (C (NCC4=CC=C (C=C4) C5=C (C) N=CS5) =O) C[C@@H] (O) C3) [C@] (C) (C) C) =O) (CC1) CC2) N6CCC (CC6) C=7C=NC (=NC7) N8C9CN (CC8CC9) C=%10C=C (N=NC%10N) C%11=C (O) C=CC=C%11

Molecular Formula

C57H72N12O5S

Molecular Weight

1037.32

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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