PROTAC SMARCA2/4-degrader-20
PROTAC SMARCA2/4-degrader-20 (I-405) is a potent, cell-permeable degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4. It demonstrates sub-100 nM DC50 for SMARCA2 degradation in MV411 and A549 cells, enabling functional studies in oncology and epigenetics research both in vitro and in vivo.
Product Specifications
CAS Number
2568277-38-1
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@@H]5CC[C@@H] (C (N[C@H] (C (=O) N6[C@H] (C (NCC7=C (OC (F) (F) F) C=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C50H58F3N11O6S
Molecular Weight
998.13
Storage Conditions
-20°C
Notes
For research use only.
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