PROTAC SMARCA2/4-degrader-5
Compound I-437 is a potent PROTAC degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4. It demonstrates cellular activity with DC50 values below 100 nM for SMARCA2 and between 100-500 nM for SMARCA4 in MV411 cells, making it a valuable chemical probe for oncology and epigenetics research.
Product Specifications
CAS Number
2568277-84-7
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5=CC=C (C[C@@H]6CC[C@@H] (C (N[C@H] (C (=O) N7[C@H] (C (NCC8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) [C@] (C) (C) C) =O) CC6) C=C5) C=C (N=N1) C%10=C (O) C=CC=C%10
Molecular Formula
C56H65N11O5S
Molecular Weight
1004.25
Storage Conditions
-20°C
Notes
For research use only.
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