MCHR1 antagonist 4

Compound 2m (MCHR1 antagonist 4) is a potent, brain-penetrant small molecule antagonist of both human and rat MCHR1 (Ki = 0.74 nM and 0.76 nM, respectively) . It is utilized in obesity and metabolic disorder research, with applications in both in vitro receptor binding studies and in vivo models for evaluating anti-obesity efficacy.