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ZW-1226

ZW-1226 is a potent and selective MRP1 (ABCC1) inhibitor, achieving 65% inhibition of MRP1-mediated transport at 5 μM in a glutathione-dependent manner. It shows high selectivity over P-gp, BCRP, MRP2, and MRP3, making it a valuable chemical probe for investigating multidrug resistance in cancer research, both in vitro and in vivo.

Product Specifications

CAS Number

2351940-23-1

Smiles

N#CC=1C=CC=2C=C3C (=O) NC (=O) N=C3N (C4=CC=C (OCC=5C=CC=CC5) C=C4) C2C1

Molecular Formula

C25H16N4O3

Molecular Weight

420.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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