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KRAS inhibitor-25

KRAS inhibitor-25 (compound 151a) is a potent pyrido[2,3-d]pyrimidine-based inhibitor effective against KRAS wild-type and mutants including G12V and G12R, with IC50 values under 100 nM. It is a valuable chemical probe for in vitro biochemical and cellular studies targeting oncogenic KRAS-driven cancers.

Product Specifications

CAS Number

3030577-05-7

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Smiles

C (OC1=NC2=C3C (=N1) C (F) =C (N=C3) C=4C (=C (Cl) C=C (O) C4) CCCCCCC5 (O) CN2CCC5) [C@@]67N (C[C@H] (F) C6) CCC7

Molecular Formula

C32H38ClF2N5O3

Molecular Weight

614.13

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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