PROTAC SMARCA2/4-degrader-19
PROTAC SMARCA2/4-degrader-19 (I-412) is a heterobifunctional molecule that induces the degradation of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4. It demonstrates potent degradation activity (DC50 < 100 nM) in cellular models such as MV411 and A549 cell lines, providing a chemical probe for oncology and epigenetic research.
Product Specifications
CAS Number
2568277-57-4
Field of Research
Neuroscience
Smiles
CC1=NC (N2C3CN (CC2CC3) C=4C=C (N=NC4N) C5=C (O) C=CC=C5) =NC=C1[C@@H]6CC[C@@H] (C (N[C@H] (C (=O) N7[C@H] (C (NCC8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) (C) C) =O) CC6
Molecular Formula
C50H61N11O5S
Molecular Weight
928.16
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042895-100 1x 100 µL
C-Myc Oncoprotein (MYC2895R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNCB0732-500 1x 500 µL
TAG-72 / CA72.4 (CC49), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details