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COMT-IN-1

COMT-IN-1 (C12) is an orally bioavailable nitrophenol-based inhibitor with high selectivity for catechol-O-methyltransferase (IC50=0.37 μM) over MAO-A/B. It crosses the blood-brain barrier, chelates metal ions, elevates cerebral dopamine, and has shown efficacy in ameliorating MPTP-induced Parkinson's disease symptoms in murine models.

Product Specifications

CAS Number

2987884-27-3

Field of Research

Signal Transduction

Smiles

FC1=CC=CC (COC (C=C2) =CC=C2CNC (/C (C#N) =C/C3=CC ([N+] ([O-]) =O) =C (C (O) =C3) O) =O) =C1

Molecular Formula

C24H18FN3O6

Molecular Weight

463.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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