PROTAC SMARCA2/4-degrader-11

SMARCA2 degrader-1 (I-321) is a potent PROTAC molecule that effectively degrades SMARCA2 with a DC50 below 100 nM. Its bifunctional design links a SMARCA inhibitor to an E3 ligase ligand, enabling targeted protein degradation for probing SMARCA2 biology in cancer research models, both in vitro and in vivo.