PROTAC SMARCA2/4-degrader-11
SMARCA2 degrader-1 (I-321) is a potent PROTAC molecule that effectively degrades SMARCA2 with a DC50 below 100 nM. Its bifunctional design links a SMARCA inhibitor to an E3 ligase ligand, enabling targeted protein degradation for probing SMARCA2 biology in cancer research models, both in vitro and in vivo.
Product Specifications
CAS Number
2568276-71-9
Field of Research
Neuroscience
Smiles
O=C1NC (=O) C (N2C (=O) N (C=3C2=CC=CC3C4CCC (N5CCC (N6N=CC (=C6) C=7C=C (N=NC7N) C=8C=CC=CC8O) CC5) CC4) C) CC1
Molecular Formula
C37H41N9O4
Molecular Weight
675.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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