PROTAC SMARCA2/4-degrader-6
PROTACSMARCA2/4-degrader-6 (I-438) is a heterobifunctional degrader that selectively targets SMARCA2 and SMARCA4 proteins for proteasomal degradation. It serves as a valuable chemical probe for investigating SWI/SNF chromatin remodeling complex function in oncology research, with utility demonstrated in both cellular and in vivo models.
Product Specifications
CAS Number
2568277-87-0
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@@H]5CC[C@@H] (C (N[C@H] (C (=O) N6[C@H] (C (N[C@@H] (C) C7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C50H61N11O5S
Molecular Weight
928.16
Storage Conditions
-20°C
Notes
For research use only.
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