AR Degrader-2
AR Degrader-2 (Compound 2) is a small molecule that induces degradation of the androgen receptor (AR), with a DC50 of 0.3-0.5 μM in VCaP prostate cancer cells. This tool compound is used in vitro to study AR-dependent signaling and prostate cancer mechanisms, supporting research into targeted protein degradation therapies.
Product Specifications
CAS Number
3023359-76-1
Smiles
O ([C@@H]1C (C) (C) [C@@H] (NC (=O) C2=CC=C (C=C2) N3CCC (C (=O) N4CCN (C (/C (=C/C (C) (C) C) /C#N) =O) CC4) CC3) C1 (C) C) C5=CC (Cl) =C (C#N) C=C5
Molecular Formula
C40H49ClN6O4
Molecular Weight
713.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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