PROTAC SMARCA2/4-degrader-17
PROTAC SMARCA2/4-degrader-17 (I-345) is a potent, cell-permeable small molecule that selectively degrades the SMARCA2 and SMARCA4 bromodomain proteins via the ubiquitin-proteasome system. With DC50 values below 100 nM in cellular assays, it is a valuable chemical probe for studying SWI/SNF complex function in cancer biology and targeted protein degradation research.
Product Specifications
CAS Number
2568276-88-8
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5=C (C) C=C (CC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) C=C5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C51H57N11O5S
Molecular Weight
936.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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