Anticancer agent 249

Anticanceragent 249 (Compound 89) is a small molecule Hsp90β inhibitor with an IC50 of 16.5 μM. It demonstrates broad in vitro antiproliferative activity against breast cancer cell lines (IC50 1.8-5.3 μM), induces apoptosis, and shows in vivo antitumor efficacy in mouse models.