OPB-171775
OPB-171775 is a molecular glue degrader that induces a ternary complex between PDE3A and SLFN12, leading to SLFN12 RNase-mediated cell death and GCN2 pathway activation. It has demonstrated antitumor activity in both cellular assays and in vivo models, supporting its investigation as a potential cancer therapeutic agent.
Product Specifications
CAS Number
2131210-15-4
Field of Research
Stem Cell & Developmental Biology
Smiles
FC1=C (C=CC (OCC (C) (C) O) =C1F) C=2[C@H] (C) CC (=O) NN2
Molecular Formula
C15H18F2N2O3
Molecular Weight
312.31
Storage Conditions
-20°C
Notes
For research use only.
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