PROTAC PARP1 degrader-2

PROTACPARP1 degrader-2 (Compound 72) is a potent and cell-permeable PARP-targeting PROTAC, demonstrating a DC50 below 10 nM in MDA-MB-231 cells and inhibiting viability in MDA-MB-436 cells with an IC50 under 100 nM. It serves as a valuable chemical tool for investigating PARP biology and targeted protein degradation in cancer research models, both in vitro and in vivo.