PROTAC SMARCA2/4-degrader-18
PROTAC SMARCA2/4-degrader-18 (I-348) is a potent, cell-permeable degrader of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4, demonstrating DC50 values below 100 nM in A549 and MV411 cell lines. This tool compound is valuable for probing SWI/SNF complex function in cancer biology and targeted protein degradation research, both in vitro and in vivo.
Product Specifications
CAS Number
2568276-91-3
Field of Research
Neuroscience
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) C5CCN (CC6=CC=C (C (N[C@H] (C (=O) N7[C@H] (C (NCC8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) [C@] (C) (C) C) =O) C=C6) CC5) C=C (N=N1) C%10=C (O) C=CC=C%10
Molecular Formula
C55H64N12O5S
Molecular Weight
1005.24
Storage Conditions
-20°C
Notes
For research use only.
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