AP14145
AP14145 is a selective small molecule inhibitor of small conductance calcium-activated potassium channels KCa2.2 and KCa2.3 (IC50 = 1.1 μM) . It exhibits antiarrhythmic properties by prolonging the atrial effective refractory period and has been shown to convert atrial fibrillation to sinus rhythm in preclinical porcine models of heart dysfunction.
Product Specifications
CAS Number
1446770-54-2
Smiles
N (C (C) =O) C1=C2C (N=C (N[C@H] (C) C3=CC (C (F) (F) F) =CC=C3) N2) =CC=C1
Molecular Formula
C18H17F3N4O
Molecular Weight
362.35
Storage Conditions
-20°C
Notes
For research use only.
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