Exatecan intermediate 9
Exatecan intermediate 9 is a synthetic precursor to Exatecan (DX-8951), a potent topoisomerase I inhibitor (IC50 = 2.2 μM) . This cytotoxin is widely employed in ADC development and has demonstrated antitumor activity in both in vitro assays and in vivo xenograft models.
Product Specifications
CAS Number
2290562-59-1
Field of Research
Pharmacology & Drug Discovery
Smiles
N (C (C) =O) C1C2=C3C (C=4N (C3) C (=O) C5=C (C4) [C@] (CC) (O) C (=O) OC5) =NC=6C2=C (CC1) C (C) =C (F) C6
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
Storage Conditions
-20°C
Notes
For research use only.
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