IKZF3 degrader 1
Compound 19a (IKZF3 Degrader 1) is a potent and effective molecular glue degrader of IKZF3, demonstrating an EC50 of 12 nM. It functions by recruiting IKZF3 to the CRBN E3 ubiquitin ligase, leading to its ubiquitination and proteasomal degradation. This tool compound is valuable for probing IKZF3 biology in hematological and immunological research contexts, both in vitro and in vivo.
Product Specifications
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Molecular Formula
C25H18BrCl3N2O5
Molecular Weight
612.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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