Pan-RAS-IN-6

Pan-RAS-IN-6 is a potent and selective DUSP6 inhibitor that suppresses MAPK signaling, demonstrating significant tumor growth inhibition and regression in NSCLC brain metastasis models. It exhibits high potency against key KRAS mutants (G12C, G12D, G12V) with low nanomolar IC50 values, making it a valuable tool for investigating KRAS-driven cancers in both in vitro and in vivo studies.