SMART1
SMART1 is a CRBN-dependent PROTAC that selectively degrades Smurf1. It demonstrates anti-tumor activity in KRAS-mutant colorectal cancer xenograft models by disrupting the PDK1-Akt signaling axis, making it a valuable tool for studying targeted protein degradation and oncogenic signaling in vitro and in vivo.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C40H35N9O7
Molecular Weight
753.76
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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