Bcl-2-IN-21

Bcl-2-IN-21 (C1) is an iridium (III) -based complex that acts as a Bcl-2 inhibitor, disrupting mitochondrial function to induce apoptosis via Bax upregulation and caspase-3 activation. It demonstrates potent anti-proliferative activity in vitro by suppressing cancer cell colony formation and has shown efficacy in vivo in murine tumor models.