PROTAC SMARCA2/4-degrader-31
PROTAC SMARCA2/4-degrader-31 (I-280) is a potent, cell-permeable small molecule that induces degradation of the SWI/SNF catalytic subunits SMARCA2 and SMARCA4. It demonstrates DC50 values below 100 nM in cellular models like A549 and MV411 cells, serving as a critical chemical probe for oncology and epigenetics research.
Product Specifications
CAS Number
2568273-83-4
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1N (C=2C (=CC (=CC2) [C@@H]3CC[C@H] (CC3) N4CCC (CC4) C=5N=C (C=CN5) N6C7CN (CC6CC7) C=8C=C (N=NC8N) C9=C (O) C=CC=C9) N1C) C%10C (=O) NC (=O) CC%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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