Z21115
Z21115 is a potent and orally active PDE4 inhibitor, specifically targeting PDE4D7 (IC50 = 10.5 nM) . It reduces pro-inflammatory markers like IL-6 and TNF-α in vitro and shows efficacy in a DSS-induced colitis mouse model, demonstrating anti-inflammatory activity with a high tolerability profile.
Product Specifications
CAS Number
2958668-54-5
Field of Research
Metabolism Research
Smiles
FC (F) OC1=CC=C (C=2C=C (OC) C (OC) =C (OC) C2) C3=CN (N=C13) C4CC4
Molecular Formula
C20H20F2N2O4
Molecular Weight
390.38
Storage Conditions
-20°C
Notes
For research use only.
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