KU004
KU004 is a novel quinazoline-based dual EGFR/HER2 inhibitor. It demonstrates anticancer activity by blocking HER2/EGFR and downstream Akt/Erk signaling, inducing G1 arrest and extrinsic apoptosis in SKBR3 breast cancer cells in vitro. This mechanism supports its research use in studying targeted oncology pathways.
Product Specifications
CAS Number
1260401-93-1
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=P1 (C) CCN (CC#CC=2C=CC3=NC=NC (NC4=CC=C (OCC=5C=CC=C (F) C5) C (Cl) =C4) =C3C2) CC1
Molecular Formula
C29H27ClFN4O2P
Molecular Weight
548.98
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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