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KU004

KU004 is a novel quinazoline-based dual EGFR/HER2 inhibitor. It demonstrates anticancer activity by blocking HER2/EGFR and downstream Akt/Erk signaling, inducing G1 arrest and extrinsic apoptosis in SKBR3 breast cancer cells in vitro. This mechanism supports its research use in studying targeted oncology pathways.

Product Specifications

CAS Number

1260401-93-1

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

O=P1 (C) CCN (CC#CC=2C=CC3=NC=NC (NC4=CC=C (OCC=5C=CC=C (F) C5) C (Cl) =C4) =C3C2) CC1

Molecular Formula

C29H27ClFN4O2P

Molecular Weight

548.98

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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