Aristeromycin

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].

Product Specifications

CAS Number

[19186-33-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; S-adenosylhomocysteine hydrolase (SAHH)

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/aristeromycin.html

Purity

99.34

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@@H]1[C@H](O)[C@@H](CO)C[C@H]1N2C3=NC=NC(N)=C3N=C2

Molecular Formula

C11H15N5O3

Molecular Weight

265.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146.|[2]Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983; (12) :119-22.