N-Acetyl-L-tyrosine

N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer[1][2][3].

Product Specifications

CAS Number

[537-55-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/N-Acetyl-L-tyrosine.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C11H13NO4

Molecular Weight

223.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Bjelton, Lilian, et al. N-acetyl-L-tyrosine as a source of tyrosine in intravenous nutrition an experimental study in the rat. Nutrition Research 9.5 (1989) : 555-564.|[2]Matsumura T, et al. N-acetyl-l-tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals. EMBO Rep. 2020 May 6;21 (5) :e49211.|[3]Kumar R, et al. Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators. Eur J Med Chem. 2007 Apr;42 (4) :503-10.