Pyrotinib maleate
Pyrotinib maleate (SHR-1258 maleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively; displays high selectivity in a panel of different kinases such as KDR, c-Kit, PDGFRβ, c-Src and c-Met (c-Src with an IC50 of 790 nM, and others >3,000 nM) ; exhibits robust anti-tumor effects on HER2-overexpressing xenograft models and sufficiently safety windows in animals as well as favorable pharmacokinetic properties in human.Breast Cancer Phase 3 Clinical.
Product Specifications
CAS Number
1397922-61-0
Product Name Alternative
SHR-1258 maleate | SHR1258 maleate
Purity
>98% (HPLC)
Solubility
H2O : ≥ 106 mg/mL 130.03 mM
Smiles
CCOC1=C (C=C2C (=C1) N=CC (=C2NC3=CC (=C (C=C3) OCC4=CC=CC=N4) Cl) C#N) NC (=O) C=CC5CCCN5C.C (=CC (=O) O) C (=O) O.C (=CC (=O) O) C (=O) O
Molecular Formula
C36H35ClN6O7
Molecular Weight
699.161
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R, E) -N- (4- ((3-chloro-4- (pyridin-2-ylmethoxy) phenyl) amino) -3-cyano-7-ethoxyquinolin-6-yl) -3- (1-methylpyrrolidin-2-yl) acrylamide dimaleate
Available Sizes
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