PF-06855800
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM; demonstrates antiproliferative activity in Z-138 cancer cells with IC50 of 1 nM, also shows anti-tumor activity in Z-138 mice xenograft models.
Product Specifications
CAS Number
1989620-04-3
Product Name Alternative
PF06855800
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (316.63 mM)
Smiles
NC1=C2C (N ([C@H]3[C@@H] ([C@@H] ([C@@H] ([C@@H] (C4=CC=C (Cl) C (F) =C4) O) O3) O) O) C=C2) =NC=N1
Molecular Formula
C19H18ClFN2O4
Molecular Weight
392.811
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2R,3S,4R,5R) -2- ((R) - (4-chloro-3-fluorophenyl) (hydroxy) methyl) -5- (4-methyl-1H-pyrrolo[3,2-c]pyridin-1-yl) tetrahydrofuran-3,4-diol
Available Sizes
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