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MRT-68921 hydrochloride

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.

Product Specifications

CAS Number

2080306-21-2

Product Name Alternative

MRT 68921 hydrochloride | MRT68921 hydrochloride

Purity

>98% (HPLC)

Solubility

H2O: 10 mg/mL

Smiles

CN1CCC2=C (C1) C=CC (=C2) NC3=NC=C (C (=N3) NCCCNC (=O) C4CCC4) C5CC5.Cl.Cl

Molecular Formula

C25H35ClN6O

Molecular Weight

471.038

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[ (1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl) amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:2)

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