NPD10084

NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1].

Product Specifications

CAS Number

[1040706-91-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Pyruvate Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/npd10084.html

Purity

99.69

Solubility

DMSO : ≥ 100 mg/mL

Smiles

COC1=CC=CC2=C1C=C(C(N3CCC4=C(C5=CC=CC=C5N4)C3)=O)N2

Molecular Formula

C21H19N3O2

Molecular Weight

345.39

Precautions

H315, H319, H320

References & Citations

[1]Nagasawa I, et al. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol. 2020 Feb 20;27 (2) :186-196.e4.