MK-0974
A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM; shows >10,000-fold selectivity in a panel of assays representing over 160 receptors, transporters, and enzymes; inhibits CGRP-stimulated cAMP production in E10 cells with IC50 of 2.2 nM; inhibits the capsaicin-induced increase in dermal blood flow in monkey models.Migraine Phase 3 Discontinued.
Product Specifications
CAS Number
781649-09-0
Product Name Alternative
Telcagepant
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1CCC (N (C2=CC=CN=C2N3) C3=O) CC1) N[C@H]4C (N (CC (F) (F) F) C[C@H] (C5=CC=CC (F) =C5F) CC4) =O
Molecular Formula
C26H27F5N6O3
Molecular Weight
566.523
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperidinecarboxamide, N-[ (3R,6S) -6- (2,3-difluorophenyl) hexahydro-2-oxo-1- (2,2,2-trifluoroethyl) -1H-azepin-3-yl]-4- (2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl) -
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