Gaboxadol HCl

Gaboxadol (hydrochloride) is a GABAA receptor agonist. (In Vitro) :Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with 8.1 x 10-6 cm·s-1, 6.1 x 10-1 cm·s-6 and 5.6 x 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively. (In Vivo) :Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice.