Sauristolactam

Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL) -induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation[2].

Product Specifications

CAS Number

[128533-02-8]

Product Name Alternative

Saurolactam

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Sauristolactam.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=C3C1=CC(O)=C(C3=C4C(C=CC=C4)=C2)OC)C

Molecular Formula

C17H13NO3

Molecular Weight

279.29

References & Citations

[1]Kim SR, et al. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production. Planta Med. 2004 May;70 (5) :391-6.|[2]Li Z, et al. Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells. Cell Biochem Biophys. 2015 Jul;72 (3) :719-26.