CYP1B1 ligand 3

Compound A1 is a potent and selective CYP1B1 inhibitor with an IC50 of 11.9 nM. It serves as a key chemical tool for in vitro enzymatic studies and as a precursor for synthesizing PROTAC CYP1B1 Degrader-2, facilitating research into CYP1B1's role in disease pathways.