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PLX-3618

PLX-3618 is a potent monovalent degrader of BRD4 (DC50 = 12.2 nM) that operates via DCAF11-mediated ubiquitination and proteasomal degradation. It demonstrates anti-proliferative and pro-apoptotic activity in AML and other cancer cell lines, with confirmed efficacy in mouse models of acute myeloid leukemia.

Product Specifications

CAS Number

2851986-76-8

Field of Research

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Purity

99.71% (May vary between batches)

Smiles

CC=1C2=C (N3C ([C@H] (CC (N) =O) N=C2C4=CC=C (C=C4) C5=CC (NC (=O) C6=C7N (N=C6) C=CC=N7) =CC=C5) =NN=C3C) SC1C

Molecular Formula

C32H27N9O2S

Molecular Weight

601.68

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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