GSK-3β inhibitor 17
This small molecule GSK-3β inhibitor, designated 17 (compound 5 n), demonstrates dose-dependent suppression of cisplatin-induced p-p65 and KIM-1 protein expression in HK-2 cells. At 32 μM, it also reduces mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1), highlighting its utility for in vitro research on acute kidney injury (AKI) and inflammatory signaling pathways.
Product Specifications
CAS Number
2521624-67-7
Field of Research
Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (OC) C=1SC (=CC1) S (=O) (=O) NC=2C=CC (=CC2) C3=NC (=NO3) C=4C=CN=C (C4) NC5=CC=C (OC (F) (F) F) C=C5
Molecular Formula
C26H18F3N5O6S2
Molecular Weight
617.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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