IGF-1R modulator 1
IGF-1R modulator 1 (Example 5) is a small molecule inhibitor of IGF-1R, FGFR1, TrkA, and TrkB with EC50 values ranging from 0.25 to 0.39 μM. It serves as a research tool for studying neurodegenerative conditions like Alzheimer's disease in both cellular and animal models of impaired neurotrophic signaling.
Product Specifications
CAS Number
2375424-89-6
Field of Research
Cardiovascular Research, Immunology & Inflammation, Signal Transduction
Smiles
O=C1NC (=O) N (C2=CC=C (OC=3C=CC=CC3) C (=C2) C) C (=O) N1C=4C=CC=CC4
Molecular Formula
C22H17N3O4
Molecular Weight
387.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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