HRS 4642
HRS 4642 is a potent and selective long-acting KRAS G12D inhibitor (Kd = 0.083 nM) that blocks MEK/ERK signaling, demonstrating antitumor efficacy in research models. It reduces tumor burden and, alone or combined with agents like Carfilzomib, promotes an immunocompetent tumor microenvironment in preclinical studies.
Product Specifications
CAS Number
2836263-09-1
Product Name Alternative
HRS4642, HRS-4642
Field of Research
Signal Transduction
Purity
99.17% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (7.9 mM) ; DMSO:≥ 80 mg/mL
Smiles
C (OC=1N=C2C3=C (N1) C (F) =C (N=C3OC[C@]4 (N2C[C@@]5 (N[C@]4 (CC5) [H]) [H]) [H]) C=6C7=C (C=CC (F) =C7CC) C=C (O) C6) [C@@]89N (C[C@H] (F) C8) CCC9
Molecular Formula
C34H35F3N6O3
Molecular Weight
632.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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