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TNF-α-IN-18

TNF-α-IN-18 (Compound 61) is a potent TNF-α inhibitor (IC50 = 1.8 μM) that suppresses NF-κB nuclear translocation. It demonstrates low cytotoxicity (CC50 > 50 μM in LM cells) and has shown protective efficacy in murine models of sepsis and rheumatoid arthritis, making it a valuable research tool for inflammation and autoimmune disease studies.

Product Specifications

CAS Number

1272322-42-5

Field of Research

Cell Biology, Immunology & Inflammation, Signal Transduction

Purity

99.77% (May vary between batches)

Solubility

DMSO:80 mg/mL (237.62 mM)

Smiles

O=C (O) C=1C (=O) C2=CC=C (Cl) C=C2OC1C=3C=C (F) C=CC3F

Molecular Formula

C16H7ClF2O4

Molecular Weight

336.67

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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