TNF-α-IN-18
TNF-α-IN-18 (Compound 61) is a potent TNF-α inhibitor (IC50 = 1.8 μM) that suppresses NF-κB nuclear translocation. It demonstrates low cytotoxicity (CC50 > 50 μM in LM cells) and has shown protective efficacy in murine models of sepsis and rheumatoid arthritis, making it a valuable research tool for inflammation and autoimmune disease studies.
Product Specifications
CAS Number
1272322-42-5
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Purity
99.77% (May vary between batches)
Solubility
DMSO:80 mg/mL (237.62 mM)
Smiles
O=C (O) C=1C (=O) C2=CC=C (Cl) C=C2OC1C=3C=C (F) C=CC3F
Molecular Formula
C16H7ClF2O4
Molecular Weight
336.67
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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