Fumagilin-105
Fumagilin-105 is an AUTOTAC molecule that induces self-oligomerization of p62, leading to targeted autophagic degradation. It demonstrates potent activity with a DC50 of 0.7 μM against MetAP2 in HEK293 cells, making it a valuable tool for studying autophagy and targeted protein degradation in cellular models.
Product Specifications
CAS Number
2410081-58-0
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Smiles
C[C@@]1 ([C@@]2 ([C@@]3 (CO3) CC[C@@H] (OC (/C=C/C=C/C=C/C=C/C (NCCOCCOCCNCC4=CC (OCC5=CC=CC=C5) =CC=C4) =O) =O) [C@H]2OC) [H]) [C@@H] (CC=C (C) C) O1
Molecular Formula
C46H60N2O9
Molecular Weight
784.98
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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