PROTAC CDK4/6 degrader 1

Compound 7f (PROTAC CDK4/6 degrader 1) is a potent dual degrader of CDK4 (DC50=10.5 nM) and CDK6 (DC50=2.5 nM) . It induces G1 phase arrest and apoptosis, inhibiting proliferation in Jurkat cells (IC50=0.18 μM), and is a valuable tool for cancer research in vitro.