EGFR-IN-117

EGFR-IN-117 (Compound 8h) is a potent and selective EGFR inhibitor effective against multiple resistant mutations, including L858R/T790M/C797S. It demonstrates nanomolar IC50 values in cell lines like H1975 and PC-9 and has shown in vivo anti-tumor efficacy in mouse models, supporting its use in oncology research targeting EGFR-driven cancers.