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PHTPP-1304

PHTPP-1304 is an AUTOTAC-based small molecule that potently degrades ERβ (DC50 ~2 nM) by inducing p62 self-oligomerization and forming p62/ERβ puncta to engage autophagy. This compound is a valuable chemical probe for studying targeted protein degradation and autophagic flux in cellular models of cancer and endocrine research.

Product Specifications

CAS Number

2410081-60-4

Field of Research

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Smiles

C (F) (F) (F) C=1N2C (=C (C (=N2) C3=CC=CC=C3) C4=CC=C (OCCOCCOCCNC[C@H] (COC5=CC (OCCCC6=CC=CC=C6) =C (OCC7=CC=CC=C7) C=C5) O) C=C4) N=C (C (F) (F) F) C1

Molecular Formula

C51H50F6N4O7

Molecular Weight

944.96

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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