TYRA-300
TYRA-300 is a potent and selective oral inhibitor of FGFR3 (IC50 = 11 nM), demonstrating significant selectivity over other FGFR isoforms. It is a research compound for investigating metastatic urothelial carcinoma and chondrodysplasia, with utility in both in vitro cellular assays and in vivo preclinical models.
Product Specifications
CAS Number
2800223-30-5
Product Name Alternative
TYRA300, TYRA-300-B01
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.66% (May vary between batches)
Solubility
DMSO:80 mg/mL (142.99 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (8.94 mM)
Smiles
S (C) (=O) (=O) N1CC2 (CN (C2) C3=CC=C (C=N3) C=4C=5C (NN4) =CC=C (O[C@H] (C) C=6C (Cl) =CN=CC6Cl) C5) C1
Molecular Formula
C25H24Cl2N6O3S
Molecular Weight
559.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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